Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Toni returns to the country and faces off with Mary.
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Sam and Dean get caught in a dangerous situation and only have each other to rely on. The fight between the American Hunters and the British Hunters comes to a head.
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Season 13 begins with Sam and Dean picking up the pieces after the loss of their mother, the demise of Crowley and the heartbreaking death of Castiel.
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Sam and Dean explore Jack's powers, but a visit from Donatello makes them realize that Jack will need more protection than they can provide. There is a new Prince of Hell in town, Asmodeus, and he sets his sights on Jack.
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Missouri's friend is murdered by a wraith with a taste for psychics, so she enlists the help of Dean and Jody to protect her granddaughter, Patience, who has no idea she shares her grandmother's trait .
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When multiple patients of grief counselor Mia Vallens turn up dead, Sam, Dean and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
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